Medical Screening and Preparation

Evidence-Based Rationale

Psychedelic therapies are safe in controlled settings with proper screening (minimal adverse events in trials). Risks (e.g., transient anxiety, blood pressure elevation) are mitigated through exclusion of high-risk individuals (psychosis, bipolar I, uncontrolled cardiovascular disease) and thorough preparation (set intentions, build rapport, regulate nervous system).

Absolute Exclusions (Contraindications)

• Current or history of primary psychotic disorder, schizophrenia, schizoaffective disorder.

• Bipolar I disorder (risk of mania activation).

• Active severe suicidality or serious risk to others (C-SSRS assessment).

• Uncontrolled hypertension or significant cardiovascular disease (arrhythmia, recent MI/stroke, QTc prolongation >450 ms males / >460 ms females).

• Pregnancy, breastfeeding, or trying to conceive.

• Severe liver impairment or acute substance use disorder (other than mild-moderate cannabis/alcohol).

• Known allergies or severe adverse reactions to relevant medicines (e.g., ketamine/esketamine).
  

Detailed Questionnaire

Please dedicate ~20 minutes to answer the following questionnaire—press ‘Submit’ when finished.